The CryoGrinder consists of a porcelain/ zirconium composite. Pestles are made of porcelain/ zirconium composite.
The CryoGrinder is a miniaturized mortar and pestle system designed to homogenize small samples (<100 mg) at low temperatures so to preserve the integrity of biomolecules. This system combines the ease of a handheld homogenizer with the efficiency of a mortar and pestle. Key features of the CryoGrinder include:
- Motor driven pestle constructed from an extremely durable porcelain/zirconium composite
- Rugged pestle with stainless steel shafts with hex bit for quick connection to the motor
- CryoGrinder can be decontaminated and sterilized via autoclave and dry heat (e.g., 200°C for 2 hr)
- Small space saving design
- Optional CryoCooler accessory valuable for chilling and transporting samples
The CryoGrinder mortar and pestle are pre-chilled in liquid nitrogen. Frozen samples are placed in the mortar and the motorized pestle is pressed down on the sample. Due to the cryogenic temperature, samples are rapidly ground into dust. Tissues from heart, lung, spleen, muscle, kidney and liver have been effectively pulverized using the CryoGrinder. Mortars are easily inverted so that ground samples can be collected into chilled tubes.
Each CryoGrinder Kit comes with a cordless handheld motor plus four mortar and pestle sets including small and large pestles. Additional mortar and pestle sets can be purchased separately.
CryoGrinder Kit:
An improvement on the traditional mortar and pestle, the CryoGrinder retains the strength and durability of porcelain while adapting to the scale of molecular biologists. The CryoGrinder was specifically designed to grind small and difficult to homogenize tissues (e.g., skin, sclera) at cryogenic temperatures. Each CryoGrinder mortar can efficiently accommodate up to 100 mg of sample, though most researchers use 10-20 mg. Two different size pestles are available which fit a standard cordless wrench/screwdriver so to ease the grinding process.
Each CryoGrinder Kit comes with four mortars, four large pestles, four small pestles, and one rechargeable cordless wrench. Detailed instructions on use and product care are also included.
When used in conjunction with the CryoCooler™, the CryoGrinder is an effective means of homogenizing multiple samples.
CryoGrinder Set:
The CryoGrinder Set is the kit minus the cordless wrench. The set consists of two porcelain/zirconium mortars, two large pestles and two small pestles. Samples can be homogenized manually or with the cordless wrench. Most standard cordless screwdrivers can be used to power the pestles.
Wrench, Cordless:
The cordless wrench is a standard 1/4" hex driver (power screwdriver) which is effective for grinding samples using an attached pestle. The wrench is rechargeable and can be used to process dozens of samples between charging. The wrench comes with a DC charger which works off of standard 120V outlets (US plug).